Effect of an experimental desensitizer with a hydroxyapatite-capsaicin composite applied before in-office dental bleaching on hydrogen peroxide diffusion, color and surface changes

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dc.contributor.authorCarpio-Salvatierra, Byron
dc.contributor.authorda Silva, Karine Leticia
dc.contributor.authorFavoreto, Michael William
dc.contributor.authorGonzález, Claudia
dc.contributor.authorRockenbach Binz Ordóñez, Maria Cristina
dc.contributor.authorLoguercio, Alessandro D.
dc.contributor.authorFarago, Paulo Vitor
dc.date.accessioned2025-03-27T06:25:03Z
dc.date.available2025-03-27T06:25:03Z
dc.date.issued2024-11-27
dc.descriptionhttps://link.springer.com/article/10.1007/s00784-024-06041-2#citeas
dc.description.abstractObjective To evaluate a prior application of an experimental desensitizer containing a hydroxyapatite-capsaicin composite (HAp-CAP) in different concentrations on hydrogen peroxide (HP) diffusion into the pulp chamber, bleaching efficacy (BE) and on physical and chemical alterations of the enamel surface after in-office bleaching. Materials and methods Forty sound premolars were randomized in five groups according to each experimental condition (n = 8): no bleaching (negative control), only bleaching (positive control), 0.1%, 1% and 5% of HAp-CAP. Four groups were submitted to in-office bleaching (HP 35%) post-desensitizer application. The HP concentration (µg/mL) on the pulp chamber was measured by UV-Vis spectrophotometer. The BE was measured by digital spectrophotometer (ΔEab, ΔE00 and ΔWID) before and after 7 days bleaching. Enamel tooth fragments obtained from twenty molars were submitted to the same experimental conditions and analyzed using FE-SEM and EDS, Vickers microhardness (VHN), Raman spectroscopy, and nanoroughness (Ra) by AFM to evaluate morphologic and chemical changes on enamel surface. All data were submitted to statistical analysis (α = 0.05). Results The groups treated with HAp-CAP exhibited a lower concentration of HP in the pulp chamber compared to only bleaching group (p < 0.05). There were no significant differences observed in BE between HAp-CAP groups and only bleaching group (p > 0.05). Only HAp-CAP 5% showed no significant differences in VHN values when compared to no bleaching group (p > 0.05). There were no significant differences among any group in Ra values (p > 0.05). The groups submitted to HAp-CAP showed a higher mineral concentration when compared to only bleaching group (p < 0.05). Conclusion Desensitizers containing HAp-CAP up to 5% effectively reduce HP diffusion into the pulp chamber after in-office bleaching, without interfering to BE and Ra, as well as prevent enamel demineralization. Clinical relevance The use of desensitizers containing HAp-CAP during in-office bleaching treatments offers a promising approach to reduce the risk of pulp irritation caused by hydrogen peroxide diffusion, without compromising the bleaching effectiveness or causing surface roughness.
dc.identifier.issn14326981
dc.identifier.issn14363771
dc.identifier.urihttps://dspace.uhemisferios.edu.ec/handle/123456789/2055
dc.language.isoen
dc.publisherClinical Oral Investigations
dc.relation.ispartofseries659
dc.titleEffect of an experimental desensitizer with a hydroxyapatite-capsaicin composite applied before in-office dental bleaching on hydrogen peroxide diffusion, color and surface changes
dc.title.alternativeEfecto de un desensibilizador experimental con un composite de hidroxiapatita-capsaicina aplicado antes del blanqueamiento dental en el consultorio sobre la difusión del peróxido de hidrógeno y los cambios de color y superficie
dc.typeArticle
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